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Creatina: anni di test e affidabilitą di assunzione

di Marco Neri  


I contenuti delle risposte di questo articolo non hanno alcuna valenza prescrittiva, ma solo informativa e culturale. I nostri "suggerimenti" scaturiscono da domande reali poste di sovente in palestra. ABC-FITNESS non fornisce un servizio di consulenza on line di questo tipo, quindi si prega di non inviare domande alla redazione e ai suoi collaboratori.

Tutti i produttori di integratori a base di creatina scrivono che il prodotto è stato testato a lungo termine. Quando è nato l'uso degli anabolizzanti nello sport e nelle palestre, dicevano la stessa cosa. Gli anabolizzanti hanno cominciato ad uccidere o a sterilizzare le persone dopo 10-15 anni di utilizzo. La creatina per quanti anni è stata testata?

All'attento e puntiglioso lettore, nonché giustamente cauto e premuroso verso la tutela della salute e dell'integrità fisica sua e dei suoi allievi (cosa che certamente fa controllando anche i livelli di nitriti e nitrati dell'acqua bevuta tutti i giorni da anni e certamente causa di molteplici patologie organiche, oppure accertandosi che i livelli di diotrazina e particolati dell'aria respirata tutti i giorni per una vita rientrino nei parametri biologicamente compatibili), alleghiamo una piccola bibliografia degli ultimi lavori reperibili sulla creatina.

Con un poco di pazienza, al suo interno troverà lavori di Poortamns, Hultaman e Miller (scusate se è poco), con osservazioni in tempi variabili da 2 agli 8 anni e con dosaggi dai 5 ai 20 g (quelli più lunghi con dosaggi giornalieri di 5/6 g). Il tutto senza alterazioni della GFR, del riassorbimento tubolare, della permeabilità della membrana glomerulare, della funzionalità epatica ecc.

Comunque al di sopra di qualsiasi studio e conclusione, il mio e nostro consiglio, riguardo non solo la Creatina, è quello di attenersi ai dosaggi riportati sulla confezione e, per assunzioni maggiori, consultarsi sempre prima con il medico.

Dopo di questo è anche giusto dire che nessuno ci può dare certezze su nulla (vedi carne, latte, proteine in polvere, farmaci, aria, acqua, rapporti amorosi, rapporti lavorativi con i soci, fedeltà coniugale, affidabilità delle banche, andamento della borsa, infallibilità della chiesa, ecc.); lo so, è triste ammetterlo, ma purtroppo viviamo in un mondo imperfetto e, personalmente, mi ritengo tale. Chi fra i lettori si può dire certo in modo assoluto e totale su qualche cosa?

Sempre in modo molto modesto e a titolo personale, mi accontento di un buon ragionamento seguito da una logica sperimentale e razionale (magari piena di buon senso) che mi consegni qualche discreta dose percentuale di possibilità, questo senza pretendere in nessun caso la certezza assoluta e dogmatica di cui ho sempre una gran paura (chissà perché, ma tendo sempre a diffidare di quelli che sanno tutto, dall'allenamento alla fisica nucleare passando per l'alimentazione e la biomeccanica).

Detta questa prolissa esposizione (di cui mi scuso), auguro buona lettura.

PS - Un signore chiamato Paracelso, che mi risulta sapesse due cose sulla chimica e sui rapporti fra uomini e con l'ambiente scriveva: "Tutto è veleno, niente è veleno, è la dose che fa il veleno".

BIBLIOGRAFIA:

ACSM The physiological and health effects of oral creatine supplementation. Med. Sci. Sports Exerc. 32, 3: 706-717, 2000

Almada A, Mitchell T, Earnest C. Impact of chronic creatine supplementation on serum enzyme concentration. FASEB J. 10:A4567, 1996

Andrews R, Greenhaff P, Curtis S, Perry A, Cowley AJ. The effect of dietary creatine supplementation on skeletal muscle metabolism in congestive heart failure. Europ. Heart J. 19: 617-622, 1998

Balsom P, Ekblom B, Sjodin B, Hultman E. Creatine supplementation and dynamic high-intensity intermittent exercise. Scand. J. Med. Sci. Sports 3:143-149, 1993

Balsom P, Söderlund K, Sjödin B, Ekblom B. Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation. Acta Physiol. Scand. 154: 303-310, 1995

Balsom PD, Söderlund K, Ekblom N. Creatine in humans with spezial refernce to creatine supplementation. Sports Med. 18(4):268-280, 1994

Becque B, Lochmann J, Melrose D. Effect of creatine supplementation during strengh training on 1 RM and body composition. Med. Sci. Sports Exerc, 29:S146, 1997.

Becque MD, Lochmann JD, Melrose Dr. Effect of oral creatine supplemtation on muscular strengh and body composition. Med. Sci. Sports Exerc. 32, 3: 654-658, 2000

Bermon S, Venembre P, Sachet C, Valor S, Dolisi C. Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults. Acta Physol. Scand. 164: 147-155, 1998

Birch R, Noble d, Greenhaff P. The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man Eur. J. Appl. Physiol. 69:268-270, 1994

Booth F.W., Tseng B.S. Olympic goal: molecular and cellular approaches to understanding muscle adaptation. NIPS, ,8, august: 165-1691993.

Bosco C, Tihanyi J, Pucspk J, Kovacs I, Gobossy A, Colli R. Effect of oral creatine supplementation on jumping and running performance. Int. J. Sports Med. 18: 369-372, 1997

Burke L, Pyne D, Telford R. Effect of oral creatine supplementation on single-effort sprint performance in elite swimmer. Int. J. Sports Nutr. 6:222-233, 1996

Casey A, Costantin-Teodosiu D, Howell D, Hultman E, Greenhaff P. Creatine ingestion favourably affects performance and muscle metabolism during maximal exercise in humans. Am. J. Physiol (Endocrinol. Metab. 34). 271: E31-E37, 1996

Cooke WH, Grandjean PW, Barnes WS. Effect of oral creatine supplementation on power output and fatigue during bicycle ergometry. J. Appl. Physiol. 78(2): 670-673, 1995

Dechent P, Pouwels PJW, Wilkem B, Hanefeld F, Frham J. Increase of total creatine in human brain after oral supllementation of creatine-monohydrate. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46):R698-R704, 1999.

DeLanghe J, De Slypere JP, De Buyzere M. Normal reference values for creatine, creatinine and carnitine are lower in vegetarians. Cil. Chem. 35:1802-1803, 1986

Earnest C, Snell P, Rodriguez R, Almada A, Mtchell T. The effect of creatine monohydrate ingestion on anaerobic power indices, muscular strength and body composition. Acta Physiol. Scand.153:207-209, 1995

Engelhardt M, Neuman G, Berbalk A, Reuter I. Creatine supplementation in nedurance sports. Med. Sci. Sports exerc. 30, 7:1123-1129, 1998

Febbraio M, Flanagan T, Snow R, Zhao S, Carey M. Effect of creatine supplementation on intramuscular TCr , metabolism and performance during intermittent, supramaximal exercise in humans. Acta Physiol. Scand. 155: 387-395, 1995

Golberg P, Bechtel P. Effects of low dose creatine supplementation on strength, speed and power by male athletes. Med. Sci. sport Exerc. 29:S251, 1997

Green A, Sewell D, Simpson E, Hultman E., Macdonald I,Greenhaff P. Creatine ingestion augments creatine uptake and glycogen synthesis during carbohydrate feeding in man. J. Physiol. 491:63, 1996-

Green A, Simpson E, Littlewood J, Macdonald I, Greenhaff P. Carbohydrate ingestion augments creatine retention during creatine feedings in human. Acta Physiol. Scand. 158: 195-202, 1996

Green Al, Hultman E, Macdonald IA, Sewell DA, Greenhaff PL. Charbohydrate ingestion augments skeletal muscle creatine accumulation during creatin supplementation in humans Am J. Physiol. 271 (Endocrinol. Metab. 34): E821-E826, 1996

Greenhaff P Renal dysfunction accompanying oral creatine supplements. The Lancet, 352, July 18, 233, 1998

Greenhaff P, Bodin K, Harris RC, Hultman E, Jones D, McIntyre D. The influence of oral creatine supplementation on muscle phosphocreatine resynthesis following intense contraction in man. J. Physiol. 467:75P, 1993

Greenhaff P, Casey A, Short A, Harris RC, Söderlund K, Hultman E. Influence of oral creatine supplementation on muscle torque during repeated bouts of maximal voluntary exercise in man. Clin. Sci. 84:565-571, 1993

Greenhaff PL, Bodin K, Söderlund K, Hultman E. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E725-E730, 1994

Grindstaff P, Kreider R, Bishop R, Wilson M, Wood L, Alexander C. Effects of creatine supplementation on repetive sprint performance and body composition in competitive swimmer. Int J. Sports Nutr. 7:330-346, 1997

Guerrero-Ontiveros ML, Wallimann T Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: down-regulation of the expression of creatine transporter isoforms in skeletal muscle. Mol Cell Biochem 1998 Jul;184(1-2):427-37

Hamilton RW, Gardner LB, Penn AS Acute tubular necrosis caused by exercise-induced myoglobinuria. Ann. Intern. Med. 77, 77, 1972

Harris RC, Söderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin. Sci. 83:367-374, 1992

Harris RC. The concentration of creatine in meat, offal and commercial dog food. Res. Vet. Sci. 62 :58-62, 1997

Harris RC Effects and safety of dietary and supplementary creatine. Meeting internazionale – Creatina: dalla scienza di base all’applicazione clinica. Milano 4 Giugno, 1999

Hespel P. Impact of creatine supplementation on muscle performance durino exercise, training and rehabilitation. Meeting internazionale – Creatina: dalla scienza di base all’applicazione clinica. Milano 4 Giugno, 1999

Hoberman HD, Sims EAH, Peters JH. Creatine and creatinine metabolism in the normal male adult syudied with the aid of isotopic nitrogen. J. Biol. Chem. 172:45-58, 1948

Hoogwerf BJ, Laine DC, Greene E. Urine C-peptide and creatinine (Jaffe method) excrection in healthy young adults on varied diets: sustained effects of varied carbohydrate protein and meat content. Am. J. Clin. Nutr. 43:350-360, 1986

Horn M, Frantz S, Remkes H, Laser A, Urban B, Mettenleiter A, Schnackerz K, Neubauer S. Effects of chronic dietary creatine feeding on cardiac energy metabolism and on creatine content in heart, skeletal muscle, brain, liver and kidney. J. Mol. Cell. Cardiol. 30: 277-284, 1998

Hultman E, Söderlund K, Timmons Ja, Cederblad G, Greenhaff PL. Muscle creatine loading in men. J. Appl. Physiol. 81(1): 232-237, 1996

Ingber D.E. Control of capillary growth and differentiation by extracellular matrix. Chest 99, Suppl 3: 34S-40S, 1991.

Ingwall J. Creatine and the control of muscle-specific protein synthesis in cardiac and skeletal muscle. Circ. Res.38:115-123, 1976

Ingwall JS, Morales MF, Stockdale FE. Creatine and the control of myosin synthesis in differentiating skeletal muscle. Proc. Nat. Acad. Sci. USA, 69(8):2250-2253

Jones AM, Atter T, Georg KP. Oral creatine supplementation improves multiple sprint performance in elite ice-hockey players. J. Sports Med. Phys. Fitness 39:189.196, 1999

Kirksey K, Warren B, Stone M, Stone M, Johnson R. The effects of six weeks of creatine monohydrate supplementation in male and female track athletes. Med. Sci. Sports Exerc. 29:S285, 1997

Koshy KM, Griswold E, Schneeberger EE. Interstitial Nephritis in a patient taking creatine, New Engl. J. Med.

Kreider RB, Ferreira M, Wilson M, Grindstaff P, Plisk S, Reinhardy J, Cantler E, Almada A. Effects of calcium ß-HMB supplementation with or without creatine during training on strength and sprint capacity. FASEB J. 11:A374, 1997

Kreider RB, Ferreira M, Wilson M, Grindstaff P, Plisk S, Reinhardy J. Effects of creatine supplementation on body composition, strength and sprint performance. Med. Sci. Sports Exerc. 30:73-82, 1998

Kreider RB, Ferreira M, Wilson M, Grindstaff P, Plisk S, Reinhardy J. Effects of ingesting a supplement designed to enhance creatine uptake on body composition during training. Med. Sci. Sports Exerc. 29:S145, 1997

Kreider RB, Grindstaff P, Wood L, Bullen D, Klesges R, Lotz D, Davis M, Cantler E, Almada A. Effects of ingesting a lean mass promoting supplement during resistance training on isokinetic performance. Med. Sci. Sports. Exerc. 28:S36, 1996

Kreider RB, Klesges R, Harmon K, Grindstaff P,Ramsey L, Bullen D, Wood L, Li Y, Almada A. Effects of ingesting supplement designed to promote lean tissue accretion on body composition during resistance exercise. Int. J. Sports Nutr. 6:234-246, 1996

Kreider RB. Creatine supplementation: analysis of ergogenic value, medical safety, and concerns. JEP online, 1,1, april, 1998

Kreis R, Kamber M, Koster M, Felblinger J, Slotboom J, Hoppeler H, Boesch C. Creatine supplementation –Part II: in vivo magnetic resonance spectroscopy. Med. Sci. Psorts Exerc. 31(12):1770-1777, 1999

Kurosawa Y, Iwane H, Hamaoka T, Shimomitsu T, Katsumura T, Sako T. Effect of oral creatine supplementation on high and low-intensity grip exercise performance. Med. Sci. Sports Exerc. 29: S251, 1997

Leenders N, Sherman WM, Lamb DR, Nelson TE. Creatine supplementation and swimming performance. Int. J. Sports. Nutr. 9:251-262, 1999

Lemon P, Boska M, Bredle D, Rogers M, Ziegenfuss T, Newcomer B. Effect of oral creatine supplementation on energetic during repeated maximal muscle contraction. Med. Sci. Sports Exerc. 27:S204, 1995

Maganaris CN, Maughan RJ. Creatine supplementation enhances maximum voluntary isometric force and endurance capacity in resistance trained men. Acta Physiol. Scand. 163:279-287, 1998

McKenna Mj, Morton J, Selig SE, Snow RJ. Creatine supplementation increases muscle total creatine but not maximal intermittent exercise performance. J. Appl. Physiol. 87(6):2244-2252, 1999

McNaughton LR, Dalton B, Tarr J. The effects of creatine supplementation on high-intensity exercise performance in elite performers. Eur. J. Appl. Physiol. 78 :236-240, 1998

Mihic S, MacDonald JR, McKenzie S, Tarnapolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med. Sci. Sports Exerc. 32,2:291-296, 2000

Mujika I, Chtard J, Lacoste L, Barale F, Geyssant A. Creatine supplementation does not improve sprint performance in competitive swimmers. Med. Sci. Sports Exerc. 28 (11):1435-1441, 1996

Mulvaney PT, Stracke ML, Woo Nam S, Woodhouse E, O’Keefe M, Clair T, Liotta LA, Khaddurah-Daouk R, Schiffmann E. Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine Kinase. Int. J. Cancer, 78:46-52. 1998

Myburgh K, Bold A, bellinger B, Wilson G, Noakes T. Creatine supplementation and sprint training in cyclist: metabolic and performance effects. Med. Sci. Sports Exerc. 28:S81, 1996

Nelson A, Day R, Glickman-Weiss E, Hegstad M, Sampson B. Creatine supplementation raises anaerobic threshold. FASEB J. 11:A589, 1997

Odland ML, MacDougall JD, Tarnopolsky MA, Elorriaga A, Norgmann A. Effect of oral creatine supplementation on muscle [PCr] and short-term maximum power output. Med. Sci. Sports Exerc. 29(2):216-219, 1997

Ööpik V, Pääsuke M, Timpmann S, Medijainen L, Ereline J, Smirnova T. Effect of creatine supplementation during rapid body mass reduction on metabolism and isokinetic muscle performance capacity. Eur. J. Appl. Physiol. 78 :83-92, 1998

Paoli A, Velussi C, Neri M, Fantin GP. Effect of creatine supplementation on mechanical power in jumping in volleyball and basketball players ICPAFR (International Council for Physical Activity and Fitness Research) Symposium ‘96, 11-14 settembre 1996, Treviso

Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal functions in healthy athletes. Med. Sci. Sports Exerc. 31,8:1108-1110, 1999

Poortmans JR, Francaux M. Renal dysfunction accompanying oral creatine supplements. The Lancet, 352, July 18, 234, 1998

Pritchard NR, Kaira PA. Renal dysfunction accompanying oral creatine supplements. The Lancet, 351, April 25:1252-1253, 1998

Redondo DR, Dowling EA, Graham BL, Almada A, Williams MH. The effect of oral creatine monohydrate supplementation on running velocity. Int. J. sports Nutr. 6: 213-221, 1993

Rico-Sanz J, Mendez Marco MT. Creatine enhances oxygen uptake and performance during alternating intensity exercise. Med. Sci. Sports Exerc. 32, 2: 379-385, 2000

Rico-Sanz J. Creatine reduces human muscle PCr and pH decrements and Pi accumulation during low-intensity exercise. J. appl. Physiol. 88:1181-1191, 2000

Robinson TM, Sewell DA, Hultman E., Greehaff PL. Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle. J. Appl. Physiol. 87(2):598-604,1999

Ropero-Miller JD, Paget-Wilkes H, Doering PL, Goldberg BA. Effect of oral creatine supplementation on random urine creatinine, pH and specific gravity measurements. Clin Chem. 46, 2:295-231, 2000

Rossiter H, Cannell E, Jakeman P. The effect of oral creatine supplementation on the 1000 m performance of competitive rowers. J. Sports Sci. 14:175-179, 1997.

Ruden T, Parcell A, Ray M, Moss K, Semler J, Sharp R. Effects of oral creatine supplementation on performance and muscle metabolism during maximal exercise Med. Sci. Sports Exerc. 28:S81, 1996

Savabi F, Carpenter CL, Mohan C, Bessman SP. The polysome as a terminal for the creatine phosphate energy shuttle. Biochem. Med. Metab. Biol. 40:291, 1988

Schaufelberg M, Swedeberg K. Is creatine supplementation helpful for patients with chronic heart failure ? 19: 533-534, 1998

Silber ML, Litvinova VN, Morozov VI, Pliskin AV, Pshendin AI, Rogozkin Va. The creatine effect on RNA and protein synthesis in growing culture of chick embrio myoblast. Biochimia. 40(4):854-860, 1975

Silber ML. Scientific facts behind creatine monohydrate as sports nutrition supplement. J. Sports Med. Phys. Fitness 39:179-188, 1999

Sipila I, Rapola J, Simell O, Vannsa A. Supplementary creatine as a treatment for gyrate atrophy of the choroids and retina. New Eng. J. Med. 304:867-870, 1981

Smith JC, Stephens DP, Hall El, Jackson AW, Earnest CP. Effect of oral creatine ingestion on parameters of the work rate-time relationship and time to exhaustion in high-intensity cycling. Eur. J. Appl. Physiol. 77 :360-365, 1998

Smith SA, Montain SJ, Matott RP, Zientara GP, Jolesz FA, Fielding RA. Effects of creatine supplementation on the energy cost of muscle contraction: a 31P-MRS study. J. Appl. Physiol. 87(1):116-123, 1999

Smith SA, Montain SJ, Matott RP, Zientara GP, Jolesz FC, Fielding RA. Creatine supplementation and age influence muscle metabolism during exercise. J. Appl. Phsyiol. 85(4):1349-1356, 1998

Snow RJ, McKenna MJ, selig SE, Jemp J, Stathis CG, Zhao S. Effect of creatine supplementation on sprint exercise performance and muscle metabolism. J. Appl. Physiol. 84(5): 1667-1673, 1998.

Stout J, Eckerson J, Ebersole K, Moore G, Perry S., Housh T, Bull A, Cramer J, Batheja A. Effect of creatine loading on neuromuscular fatigue threshold. J. Appl. Physiol. 88:109-113, 2000

Stout J, Eckerson J, Noonan D, Moore G, Culien D. The effect of a supplement designed to augment creatine uptake on exercise performance and fat free mass in football players. Med. Sci. sports Exerc. 29: S251, 1997

Terrilion KA, Kokhorst FW, Dolgener FA, Joslyn SJ. The effect of creatine supplementation on two 700-m maximal running bouts. Int. J. Sports Nutr. 7:138-143, 1997

Urbanski RL, Loy SF, Vincent WJ, Yaspelkis BB. Creatine supplementation differentially affects maximal isometric strength and the time to fatigue in large and small muscle groups.

Valtonen M, Näntö-salonen K, Jääskeläinen S, Heinänen K, Alanen A, Heinonen OJ, Lundbom N, Erkintalo M, Simell O. Central nervous system involvement in gyrate atrophy of the choroid and retina with htperorithinaemia. J. Inher. Metab. Dis. 22:855-866, 1999

Van Leemputte M, Vandenberghe K, Hhespel P. Shortening of muscle relaxation time after creatine loading. J. Appl. Physiol. 86(3):840-844, 1999

Vanakoski J, Kosunen V, Meririnne E, Seppala T. Creatine and caffeine in anaerobic and aerobic exercise: effects on physical performance and pharmacokinetic considerations. Int J Clin Pharmacol Ther 1998 May;36(5):258-62

Vandeberghe K, Goris M, VanHecke P, Van Leeputte M, Vangerven L, Hespel P. Long-term creatine intake is beneficial to muscle performance during resistance-training. J. Appl. Physiol. 83(6): 2055-2063, 1997

Vandenberghe K, Gillis N, Van Hecke P, Van Leemputte M, Vanstapel F, Hespel P. Caffeine counteracts the ergogenic action of muscle creatine loading. J. Appl. Physiol. 80(2):452-457, 1996

Vandenberghe K,Van Hecke P, Van Leemputte M, Vanstapel F, Hespel P. Phosphocreatine resynthesis is not affected by creatine loading. Med. Sci. Sports Exerc. 31, 2:236-242, 1999

Vanderburgh H.H. Mechanizal forces and their second messengers in stimulating cell growth in vitro. Am J Physiol 262: R350-R355, 1992

Veskler VI, Kuznetsov AV, Anflous K, Mateo P, van Deursen J, Wieringa B. Muscle creatine kinase-deficient mice. J. Biol. Chem. 270:1921-1929, 1995

Volek J, Kraemer W, Bush J, Boets M, Incledon T, Clark K, Lynch J. Creatine supplementation enhances muscular performance during high-intensity resistance exercise. J. Am. Diet. Ass. 97: 765-770, 1997

Volek JS, Duncan ND, Mazzetti SA, Staron RS, Ptukien M, Gomez AL, Pearson Dr, Fink WJ, Kraemer WJ. Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med. Sci, Sports Exerc. 31, 8:1147-1156, 1999

Walker JB. Metabolic control of creatine biosynthesis.1 : effect of dietary creatine. J. Biol. Chem. 235:2357-2361, 1960

Watson P.A. Function follows form: generation of intracellular signals by cell deformation. FASEB J 5: 2013-2019, 1991.

Willer B, Stucki G, Hoppeler H, Brühlmann, Krähenbühl S. Effects of creatine supplementation on muscle weakness in patients with rheumatoid arthritis. Rheumatol. 39:293-298, 2000


 



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